Size and shape of the caudate nucleus in individuals with bipolar affective disorder

D Ong; M Walterfang; GS Malhi; M Styner; D Velakoulis; C Pantelis

Journal article

Size and shape of the caudate nucleus in individuals with bipolar affective disorder

D Ong, M Walterfang, GS Malhi, M Styner, D Velakoulis, C Pantelis

Australian and New Zealand Journal of Psychiatry | Published : 2012

DOI: 10.1177/0004867412440191

Abstract

Objective: The caudate nucleus (CN) is a crucial component of the ventral striatum, which is part of a prefrontal-striatal-thalamic circuit that is modulated by limbic structures to subserve emotional processing. Bipolar disorder is thought to be underpinned by dysfunctional anterior limbic networks, although MRI studies examining the CN have shown equivocal results. As gross volumetric analyses may not detect subtle regional change, we aimed to clarify the role of the CN in bipolar disorder by undertaking shape analysis to detect regional reductions.Methods: The CN was manually traced on MRI scans from 27 patients with bipolar-I disorder and 24 matched controls. A non-parametric spherical h..

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University of Melbourne Researchers

Mark Walterfang Author

Dennis Velakoulis Author

Christos Pantelis Author

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Grants

Awarded by National Institute of Child Health and Human Development

Funding Acknowledgements

The study was supported by an NHMRC Grant and Rotary Funding held by Professor Malhi. Professor Christos Pantelis was supported by a NHMRC Senior Principal Research Fellowship (ID: 628386) and NHMRC Program Grant (ID: 566529).